Research Focus - Skinbiopsy and Peripheral Nerve

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What is a Skin Biopsy

Why do a Skin Biopsy

Fondazione IRCCS

Istituto Neurologico "C.Besta"

Publications

1. Nicolini G, Canta A, Oggioni N, Rigolio R, Cossa G, Lombardi R, Roglio I, Cervellini I, Lauria G, Melcangi RC, Bianchi R, Crippa D, Cavaletti G. Experimental epothilone B neurotoxicity: results of in vitro and in vivo studies. Neurobiol Dis, May 21 [Epub ahead of print]

2. Lauria G, Campanella A, Filippini G, Martini A, Penza P, Maggi L, Antozzi C, Ciano C, Beretta P, Caldiroli D, Ghelma F, Ferrara G, Ghezzi P, Mantegazza R. Erythropoietin in Amyotrophic Lateral Sclerosis: A pilot, randomised, double-blind, placebo-controlled study of safety and tolerability. Amyotrophic Lat Sclerosis, May 29 [Epub ahead of print]

3. Canta A, Chiorazzi A, Meregalli C, Carozzi V, Oggioni N, Lauria G, Bianchi R, Nicora MF, Cavaletti G. Continuous buprenorphine delivery effect in streptozotocine-induced painful diabetic neuropathy in rats. J Pain in press

4. Rigamonti A, Lauria G, Balgera R, Agostoni E. Subacute inflammatory polyradiculopathy associated with Sjögren’s syndrome. Muscle Nerve. 2009,39(6):855-7

5. Roglio I, Bianchi R, Camozzi F, Carozzi V, Cervellini I, Crippa D, Lauria G, Cavaletti G, Melcangi RC. Docetaxel-induced peripheral neuropathy: protective effects of dihydroprogesterone and progesterone in an experimental model. J Peripher Nerv Syst. 2009 Mar;14(1):36-44.

6. Penza P, Lombardi R, Camozzi F, Ciano C, Lauria G. Painful neuropathy in subclinical hypothyroidism: clinical and neuropathological recovery after hormone replacement therapy. Neurol Sci. 2009 Apr;30(2):149-51.

7. RMC Trial Group. Randomised controlled trial of methotrexate for chronic inflammatory demyelinating polyradiculoneuropathy (RMC trial): a pilot, multicentre study. Lancet Neurol. 2009 Feb;8(2):158-64.

8. England JD, Gronseth GS, Franklin G, Carter GT, Kinsella LJ, Cohen JA, Asbury AK, Szigeti K, Lupski JR, Latov N, Lewis RA, Low PA, Fisher MA, Herrmann D, Howard JF, Lauria G, Miller RG, Polydefkis M, Sumner AJ; American Academy of Neurology; American Association of Neuromuscular and Electrodiagnostic Medicine; American Academy of Physical Medicine and Rehabilitation. Evaluation of distal symmetric polyneuropathy: The role of laboratory and genetic testing (an evidence-based review). Muscle Nerve. 2009;39(1):116-25

9. England JD, Gronseth GS, Franklin G, Carter GT, Kinsella LJ, Cohen JA, Asbury AK, Szigeti K, Lupski JR, Latov N, Lewis RA, Low PA, Fisher MA, Herrmann D, Howard JF, Lauria G, Miller RG, Polydefkis M, Sumner AJ; American Academy of Neurology; American Association of Neuromuscular and Electrodiagnostic Medicine; American Academy of Physical Medicine and Rehabilitation. Evaluation of distal symmetric polyneuropathy: The role of autonomic testing, nerve biopsy, and skin biopsy (an evidence-based review). Muscle Nerve. 2009;39(1):106-15.

10. Lauria G, Lombardi R, Camozzi F, DevigiliG. Skin biopsy for the diagnosis of peripheral neuropathy. Histopathology. 2009 Feb;54(3):273-85.

11. J.D. England, G.S. Gronseth, G. Franklin, G.T. Carter, L.J. Kinsella, J.A. Cohen, A.K. Asbury, K. Szigeti, J.R. Lupski, N. Latov, R.A. Lewis, P.A. Low, M.A. Fisher, D. Herrmann, J.F. Howard, G. Lauria, M. Polydefkis, A.J. Summer. Practice Parameter: The evaluation of distal symmetric polyneuropathy: the role of laboratory and genetic testing (an evidence-based review). Report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation. Neurology. 2009 Jan 13;72(2):185-92.

12. J.D. England, G.S. Gronseth, G. Franklin, G.T. Carter, L.J. Kinsella, J.A. Cohen, A.K. Asbury, K. Szigeti, J.R. Lupski, N. Latov, R.A. Lewis, P.A. Low, M.A. Fisher, D. Herrmann, J.F. Howard, G. Lauria, M. Polydefkis, A.J. Summer. Practice Parameter: The evaluation of distal symmetric polyneuropathy: the role of autonomic testing, nerve biopsy, and skin biopsy (an evidence-based review) Report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation. Neurology. 2009 Jan 13;72(2):177-84

13. PenzaP, CampanellaA, MartiniA, MelliG, LombardiR, CamozziF, DevigiliG, Lauria G. Short and intermediate-term efficacy of buprenorphine TDS in chronic painful neuropathies. J Periph Nerv System, 2008;13(4):283-8.

14. Melli G, Taiana M, Camozzi F, Triolo D, Podini P, Quattrini A, Taroni F, Lauria G. Alpha-lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy. Exp Neurol. 2008;214(2):276-84

15. Devigili G, Tugnoli V, Penza P, Camozzi F, Lombardi R, Melli G, Broglio L, Granieri E, LauriaG. The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology. Brain 2008;131(Pt 7):1912-25

16. van Nes SI, Faber CG, Hamers RM, Harschnitz O, Bakkers M, Hermans MC, Meijer RJ, van Doorn PA, Merkies IS; Bennett D, van den Berg LH, Van den Bergh PY, Cornblath DR, DalakaS M, van Doorn PA, Faber CG, Gorson KC, Hadden RD, Hahn AF, Hughes RA, Lauria G, Léger JM, Lewis RA, Lunn PT, Merkies IS, Nobile-Orazio E, Noterman S NC, Padua L, Reilly MM. Revising two-point discrimination assessment in normal aging and in patients with polyneuropathies. J Neurol Neurosurg Psychiatry. 2008 Jul;79(7):832-4.

17. Magnaghi, V, Ballabio M, Camozzi F, Colleoni M, Consoli A, Gassmann M, Lauria G, Motta M, Procacci P, Trovato AE, Bettler B. Altered peripheral myelination and pain perception in mice lacking GABA-b receptors. Mol Cell Neurosci 2008;37:599–609

18. Focosi D, Kast RE, Maggi F, Lauria G, Ceccherini-Nelli L, Petrini M. 5-HT2a inhibitors for progressive multifocal leukoencephalopathy: old drugs for an old disease. J Infect Dis 2008;197(2):328

19. Solari A, Laura` M, Salsano E, Radice D, Pareyson D, On behalf of the CMT-TRIAAL Study Group. Reliability of clinical outcome measures in Charcot-Marie-Tooth disease. Neuromuscul Disord. 2008;18(1):19-26.

20. Roglio I, Giatti S, Pesaresi M, Bianchi R, Cavaletti G, Lauria G, Garcia-Segura LM, Melcangi RC. Neuroactive steroids and peripheral neuropathy. Brain Res Reviews 2008;57(2):460-9.

21. Lauria G, Lombardi R. Skin biopsy: a new tool for diagnosing peripheral neuropathy. Br Med J 2007;334(7604):1159-1162

22. Lauria G, Devigili G. Skin biopsy as a diagnostic tool in peripheral neuropathies. Nature Clinical Practice Neurology 2007, Oct;3(10):546-57.

23. Sommer C, Lauria G. Skin biopsy: a new diagnostic tool for autonomic dysfunctions in Parkinson's disease? Lancet Neurology 2007;6:849

24. Sommer C, Lauria G. The use of skin biopsy in the management of peripheral neuropathy. Lancet Neurology 2007; 6:632-642.

25. Lauria G. Recent developments in the management of peripheral neuropathy using skin biopsy. Rev Neurologique 2007;163:1266-1270

26. Marucci G, Morandi L, Bartolomei I, Salvi F, Pession A, Righi A, Lauria G, Foschini MP. Amyotrophic lateral sclerosis with mutation of the Cu/Zn superoxide dismutase gene (SOD1) in a patient with Down syndrome. Neuromuscul Disord. 2007;17(9-10):673-6.

27. Rigamonti A, Magi S, Venturini E, Morandi L, Ciano C, Lauria G. Celiac disease presenting with motor neuropathy: effect of gluten free-diet. Muscle Nerve 2007;35(5):675-677

28. Roglio I, Bianchi R, Giatti S, Cavaletti G, Caruso D, Scurati S, Crippa D, Garcia-Segura LM, Camozzi F, Lauria G, Melcangi RC. Testosterone derivatives are neuroprotective agents in experimental diabetic neuropathy. Cell Mol Life Sci 2007;64(9):1158-68.

29. Bianchi R, Giardini A, Rodriguez-Menendez V, Oggioni N, Canta A, Colombo T, De Michele G, Martone S, Sfacteria A, Piedemonte G, Grasso G, Beccaglia P, Ghezzi P, D'Incalci M, Lauria G, Cavaletti G. Cisplatin-induced peripheral neuropathy: neuroprotection by erythropoietin without affecting tumour growth. Eur J Cancer 2007;43:710-717.

30. LeonelliE, Bianchi R, Cavaletti G, Caruso D, Crippa D, Garcia-Segura LM, Lauria G, Magnaghi V, Roglio I, Melcangi RC. Progesterone and its derivatives are neuroprotective agents in experimental diabetic neuropathy: biochemical and functional analyses. Neuroscience 2007;144:1293-1304.

31. Restivo DA, Marchese-Ragona R, Lauria G, Squatrito S, Gullo D, Vigneri R. Botulinum toxin treatment for oropharyngeal dysphagia associated with diabetic neuropathy. Diabetes Care 2006;29:2650-2653.

32. Lauria G, Morbin M, Lombardi R, Capobianco R, Camozzi F, Pareyson D, Manconi M, Geppetti P. Expression of capsaicin receptor immunoreactivity in human peripheral nervous system and in painful neuropathies. J Periph Nerv Syst 2006,11:262–271

33. Bianchi R, Brines M, Lauria G, Savino C, Giardini A, Nicolini G, Rodriguez-Menendez V, Oggioni N, Canta A, Penza P, Lombardi R, Minoia C, Ronchi A, Cerami A, Ghezzi P, Cavaletti G. Protective effect of erythropoietin and of its carbamylated derivative in experimental cisplatin peripheral neurotoxicity. Clin Cancer Res 2006;12:2607-2612.

34. Merkies IS, Lauria G. 131st ENMC international workshop: selection of outcome measures for peripheral neuropathy clinical trials 10-12 December 2004, Naarden, The Netherlands. Neuromuscul Disord. 2006;16:149-156.

35. Sghirlanzoni A, Pareyson D, Lauria G. Sensory neuron diseases. Lancet Neurology 2005;4:349-361

36. Lombardi R, Erne B, Lauria G, Pareyson D, Borgna M, Morbin M, Arnold A, Czaplinski A, Fuhr P, Schaeren-Wiemers N, Steck AJ. IgM deposits on skin nerves in anti–myelin-associated glycoprotein neuropathy. Ann Neurol 2005; 57:180 –187

37. LauriaG, Majorana A, Borgna M, Lombardi R, Penza P, Padovani A, Sapelli P. Trigeminal small-fiber sensory neuropathy causes burning mouth syndrome. Pain 2005;115:332–337.

38. Lauria G. Skin biopsy in the diagnosis of peripheral neuropathies. Practical Neurology 2005;5:92-99.

39. Lauria G, Cornblath DR, Johansson O, McArthur, S.I. Mellgren, M. Nolano, N. Rosenberg, C. Sommer. EFNS Guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy. Eur J Neurol 2005;12: 747–758

40. LauriaG, LombardiR, BorgnaM, PenzaP, BianchiR, SavinoC, CantaA, Nicolini G, MarmiroliP, CavalettiG. Intraepidermal nerve fiber density in rat footpad: neuropathologic - neurophysiologic correlation. J Periph Nerv Syst 2005;10:199–205.

41. Lauria G. Small fibre neuropathy. Curr Opin Neurol 2005;18:591–597

42. Broglio L, Lauria G. Worsening after rituximab treatment in anti-MAG neuropathy. Muscle Nerve 2005; 32:378-9

43. Lauria G. Semeiologia e clinica delle neuropatie sensitive. Neurol Sci 2005;26:S301-S304.

44. Lauria G, Borgna M, Morbin M, Lombardi R, Mazzoleni G, Sghirlanzoni A, Pareyson D. Tubule and neurofilament immunoreactivity in human hairy skin: markers for intraepidermal nerve fibers. Muscle Nerve 2004;30:310-316.

45. Bianchi R, Buyukakilli B, Brines M, Savino C, Cavaletti G, Oggioni N, Lauria G, Borgna M, Lombardi R, Cimen B, Comelekoglu U, Kanik A, Tataroglu C, Cerami A, Ghezzi P. Erythropoietin both protects from and reverses experimental diabetic neuropathy. Proc Natl Acad Sci U S A 2004;10:823-828

46. Lauria G, Lombardi R, Borgna M. L'innervazione della cute nell'uomo: da Paul Langerhans alle attuali procedure diagnostiche. Neurol Sci 2004; 25:S419-S422.

47. Lauria G, Morbin M, Lombardi R, Borgna M, Mazzoleni G, Sghirlanzoni A, Pareyson D. Axonal swellings predict the degeneration of epidermal nerve fibers in painful neuropathies. Neurology 2003;61:631-636

48. Lauria G, Pareyson D, Pitzolu MG, Bazzigaluppi E. Excellent response to steroid treatment in anti-GAD cerebellar ataxia. Lancet Neurology 2003;2:634-635

49. Lauria G, Pareyson D, Sghirlanzoni A. Neurophysiological diagnosis of acquired sensory ganglionopathy. Eur Neurol 2003;50:146-152

50. Pareyson D, Testa D, Morbin M, Erbetta A, Ciano C, Lauria G, Milani M, Taroni F. Does CMT1A homozygosity cause more severe disease with root hypertrophy and higher CSF proteins? Neurology 2003;60:1721-1722.

51. Pareyson D, Sghirlanzoni A, Lauria G. Algoritmo diagnostico: dal sintomo alla causa. Polineuropatie sensitive. Neurol Sci 2003;24:S677-S680.

52. Pareyson D, Scaioli V, Ciano C, Lauria G, Sghirlanzoni A, Taroni F. Neuropatie di Charcot-Marie-Tooth: rivisitazione della neurofisiopatologia nell’era della genetica molecolare. Neurol Sci 2002;23:S461-S466

53. Lauria G, Pareyson D, Sghirlanzoni A. Sensory ganglionopathies: causes and neuroradiological findings. N Engl J Med 2002;346:1029-1030.

54. Lauria G, Sghirlanzoni A, Lombardi R, Pareyson D. Epidermal innervation in sensory ganglionopathies – Clinical and neurophysiological correlations. Muscle Nerve 2001;24:1034-1039.

55. Lauria G, Erbetta A, Pareyson D, Sghirlanzoni A. Parenchymatous neurosyphilis. Neurol Sci 2001;22:281-282.

56. Pareyson D, Lauria G, Sghirlanzoni A. La terapia con immunoglubuline (IVIg) nelle neuropatie disimmuni. Neurol Sci 2001;22:S431-S435.

57. Lauria G, Chiapparini L, Pareyson D, Sghirlanzoni A. Spinal cord lesion due to epidural anesthesia. Neurol Sci 2000;21:411-412.

58. Lauria G, Pareyson D, Grisoli M, Sghirlanzoni A. Clinical and MRI findings in chronic sensory ganglionopathies. Ann Neurol 2000;47:104-109.

59. Lauria G, Pareyson D, Sghirlanzoni A. Chronic cryptogenic sensory polyneuropathy. Arch Neurol 2000:57:759-760.

60. Pareyson D, Taroni F, Botti S, Morbin M, Baratta S, Lauria G, Ciano C, Sghirlanzoni A. Cranial nerve involvement in CMT disease type 1 due to early growth response gene mutation. Neurology 2000;54:1696-1698.

61. Sghirlanzoni A, Lauria G, Lombardi R, Pareyson D. Diagnostica differenziale delle ganglionopatie paraneoplastiche. Neurol Sci 2000;21:S273-S275.

62. Lauria G, Holland N, Hauer PE, Cornblath DR, Griffin JW, McArthur JC. Epidermal innervation: changes with aging, topographic location, and sensory neuropathy. J Neurol Sci 1999;164:172-178.

63. Lauria G. Innervation of the human epidermis. A historical review. Ital J Neurol Sci 1999;20:63-70.

64. Casetta I, Granieri E, Gilli G, Lauria G, Tola MR, Paolino E. Temporal trend and factors associated with delayed hospital admission of stroke patients. Neuroepidemiology 1999;18:255-264

65. Lauria G, McArthur JC, Hauer PE, Griffin JW, Cornblath DR. Neuropathological alterations in diabetic truncal neuropathy: evaluation by skin biopsy. J Neurol Neurosurg Psychiatry 1998;65:762-766.

66. Flanigan KM, Lauria G, Griffin JW, Kuncl RW. Age related biology and diseases of muscle and nerves. Neurologic Clinics 1998:659-669.

67. Lauria G, Gentile M, Fassetta G, et al. Transient global amnesia and transient ischemic attack: a community-based case-control study. Acta Neurol Scand 1998;97:381-385.

68. Casetta I, Granieri E, Marchi D, Murgia SB, Tola MR, Ticca A, Lauria G, Govoni V, Murgia B, Pugliatti M. An epidemiologic study of multiple sclerosis in central Sardinia, Italy. Acta Neurol Scand 1998;98:391-394.

69. Lauria G, Gentile M, Fassetta G, et al. Incidence of transient global amnesia in the Belluno province, Italy: 1985 through 1995. Results of a community-based study. Acta Neurol Scand 1997;95:303-310.

70. Barrella M, Lauria G, Quatrale R, Paolino E. Hypokaliemic rhabdomyolisis associated with liquorice ingestion: report of an atipical case. Ital J Neurol Sci 1997;18:217-220.

71. Lauria G, Gentile M, Fassetta G, et al. Incidence of transient ischemic attacks in the Belluno province, Italy. First-year results of a community-based study. Acta Neurol Scand 1996;93:291-296.

72. Granieri E, Tamburin S, Lauria G, et al. Attualità sulla malattia di Creutzfeldt-Jakob e sindromi correlate. Sorveglianza epidemiologica nell’Italia settentrionale e in Sardegna. L’Arcispedale S. Anna 1996;46:151-199.

73. Lauria G, Gentile M, Fassetta G, et al. Incidence and prognosis of stroke in the Belluno province, Italy. First-year results of a community-based study. Stroke 1995;26:1787-1793.

74. Zanchin G, De Boni A, Lauria G, Maggioni F, Rossi P, Villacara A. Synaptosomal glutamate uptake in a model of experimental cerebral ischemia. Neurochem Research 1995;20:195-199.

75. Gentile M, Lauria G. Cephalic tetanus presenting with incomplete Bell’s palsy. Ital J Neurol Sci 1994;15:111-113

76. Villacara A, Lauria G, Maggioni F, et al. Alterazioni neurotrasmettitoriali in corso di ischemia cerebrale sperimentale. In: Neurorianimazione e Neuroprotezione in Rianimazione e Terapia Intensiva - Attualitá e prospettive. San Marco, ed., Padova, 1994;27-32.

77. Gentile M, Lauria G, Perelli P, Martinelli F. La diaschisi cerebellare crociata: diagnosi differenziale fra TIA e stroke mediante HM-PAO SPECT. Neurologia Ospedaliera Italiana 1994;3:69-74.

78. Villacara A, Garbin L, Lauria G, Zanchin G, Galzigna L. Substrate-stimulated oxygen consumption by isolated rat brain microvessels in the presence and absence of ATP. Neurochem Research 1993;18:1113-1116.

Book chapters

1. Sommer C., Lauria G. Painful small fiber sensory neuropathies. In: Handbook of Clinical Neurology, PJ Vinken & GW Bruyn (eds), 2005

2. Lauria G. La gestione della cervicobrachialgia. In: Neuropatie periferiche: casi clinici. SEEd srl, Torino, Giugno 2007

3. Lauria G, Nolano M. La biopsia cutanea nella pratica clinica. In: Trattato di Neuropatologia. G.L. Mancardi, F. Tagliavini, G. Vita (eds), Elsevier: Amstredam, New York, 2005

4. Sghirlanzoni A, Lauria G, Pareyson D. Malattie del sistema nervoso periferico. In: Terapia delle malattie neurologiche con principi di diagnosi. A. Sghirlanzoni, G. Lauria, D. Pareyson, N. Nardocci (eds). Edi-Ermes: Milano, 2004

5. Lauria G. Spasticità. In: Terapia delle malattie neurologiche con principi di diagnosi. A. Sghirlanzoni, G. Lauria, D. Pareyson, N. Nardocci (eds). Edi-Ermes: Milano, 2004

6. Sghirlanzoni A, Lauria G. Complicazioni della Chemioterapia. In Le Complicazioni Neurologiche in Oncologia Caraceni A, Sghirlanzoni A, Simonetti F (Eds). Springer, Milano, 2006

7. Sghirlanzoni A, Lauria G. Complicazioni della Radioterapia. In Le Complicazioni Neurologiche in Oncologia Caraceni A, Sghirlanzoni A, Simonetti F (Eds). Springer, Milano, 2006

8. Sghirlanzoni A, Lauria G. Principali Complicazioni Neurologiche della Chirurgia Oncologica. In Le Complicazioni Neurologiche in Oncologia Caraceni A, Sghirlanzoni A, Simonetti F (Eds). Springer, Milano, 2006

Books

1. Terapia delle malattie neurologiche con principi di diagnosi. A. Sghirlanzoni, G. Lauria, D. Pareyson, N. Nardocci (eds). Edi-Ermes: Milano, 2004

2. Sghirlanzoni, G. Lauria, D. Pareyson (eds). Localizzazione delle lesioni nel Sistema Nervoso Periferico. I&V Publisher, Milano, 2001.