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RESEARCH
FOCUS
Neuropathic pain
We are interested in pain in peripheral nervous
system disease. Painful nerve diseases are a major clinical problem. We use a
well establish technique for assessing the nerve fibers carrying nociception
and temperature sensations within the skin. This is a useful tool of
investigation both in experimental animal models and in patients with nerve
diseases.
Several clinical trials investigating innovative
treatment for neuropathic pain are currently ongoing in our institution.
- Evaluation of the analgesic effect of
buprenorphine TDS administered as add on treatment in patients with
chronic neuropathic pain inadequately controlled by conventional therapy.
- Evaluation of the analgesic effect of
electro-acupuncture in chronic neuropathic pain.
- Evaluation of the analgesic activity of
pregabalin in Burning Mouth Syndrome
- Evaluation of the analgesic effects of
transdermal lidocaine vs pregabalin.in patients with diabetic neuropathy
and post-herpetic neuralgia
Experimental studies on the evaluation of opioids in animal models of
chemotherapy induced peripheral are also currently ongoing Representative
Publications
Lauria G, Morbin M, Lombardi
R, Capobianco R, Camozzi F, Pareyson D, Manconi M, Geppetti P. Expression of
capsaicin receptor immunoreactivity in human peripheral nervous system and in
painful neuropathies. J Periph Nerv Syst 2006,11:262–271
Lauria G, Majorana A, Borgna
M, Lombardi R, Penza P, Padovani A, Sapelli P. Trigeminal small-fiber sensory
neuropathy causes burning mouth syndrome. Pain 2005;115:332–337
Lauria G, Morbin M, Lombardi R, Borgna M, Mazzoleni G, Sghirlanzoni A,
Pareyson D. Axonal swellings predict the degeneration of epidermal nerve fibers
in painful neuropathies. Neurology 2003;61:631-636
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